Disintegrant definition and meaning collins english dictionary. Information and translations of disintegrant in the most comprehensive dictionary definitions resource on the web. The sodium starch glycolate was incorporated as a super disintegrant in the. Disintegrated definition of disintegrated by the free. The central role of excipients in drug formulation. Aug 26, 1983 the crushing strength, disintegration and dissolution properties of tablets, made by wet granulation with lactose as filter, gelatin as binder, potato starch as disintegrant and magnesium stearate as lubricant can be markedly improved when the potato starch 20% is replaced by a much lower concentration 4% of an insoluble super disintegrant. The oldest and probably the most widely used disintegrant, the starch is modified with a dramatic disintegrating properties and are available as explotab and primogel. These are low substituted carboxy methyl starches in granular forms. Absorption ratio, disintegration time, orodispersible tablets, porosity, wetting time.
Effect of disintegrants on the properties of multiparticulate. Pdf effect of mode of addition of disintegrants on. A design of experiments doe approach 2level full factorial design was used to investigate the effect of several formulation and process variables on the properties of fast disintegrating tablets comprising starchbased pellets and excipient granules and to optimize and validate the design space. Disintegrants are substances or mixture of substances added the drug formulation that facilitates the breakup or disintegration of tablet or capsule content into smaller particles that dissolve more rapidly than in the absence of disintegrants.
Starch amylum the mechanism of action of starch is wicking and restoration of deformed starch particles on contact with aqueous fluid and in doing so release of certain amount of stress which is responsible for disruption of hydrogen bonding formed during compression. With nounverb tables for the different cases and tenses links to audio pronunciation and relevant forum discussions free. In many cases, the disintegrant has a major role in the disintegration process, and the disintegrant use level will impact tablet hardness and mouthfeel. Disintegrants constitute a group of materials that, on contact with water, swell, hydrate, change in volume or form, or react chemically to produce a. Disintegrous definition of disintegrous by merriamwebster. Disinfectant definition of disinfectant by medical. Us4086335a pharmaceutical tablets containing chitin as a. A disintegrant is an agent, used in the preparation of tablets, which causes them to disintegrate and release their medicinal substances on contact with moisture. The choice of a suitable disintegrant and an optimal use level, therefore, are critical to ensure a high disintegration rate.
Kumar r, shirwaikar aa, shirwaikar a, prabhu sl, mahalaxmi r, rajendran k and kumar dc. Expired lifetime application number us05626,988 inventor frank n. Disintegrants act by different mechanisms, and a number of factors may affect their performance. Evaluation of the disintegrant properties of native starches. Disintegrating disintegrating is a 14 letter word starting with d and ending with g synonyms, crossword answers and other related words for disintegrating.
Comparison of superdisintegrants in orally disintegrating tablets. Disinter definition of disinter by the free dictionary. The oral absorption of nif was studied in fasted rats. Quality attribute considerations for chewable tablets. We hope that the following list of synonyms for the word disintegrating will help you to finish your crossword today. A disintegrant used in this type of formulation, simply has to break the tablet apart to expose the drug substance for dissolution. The best quality pdf to word conversion on the market free and easy to use. Disinfectant definition of disinfectant by medical dictionary. Research article evaluation of a new tablet disintegrant. The disintegrant particles with low cohesiveness and compressibility themselves act to enhance porosity and provide these pathways into the tablet. Water penetration rate and rate of disintegration force. Disintegrants and superdisintegrants are used in tablets and capsules to ensure the rapid break down into their primary particles, facilitating the dissolution or release of the active ingredients. Disintegrant definition and meaning collins english.
This is especially important for immediate release products where rapid release of drug substance is required. Pearlitol flash mannitolstarch compound is an innovative coprocessed excipient for orodispersible tablets. When it comes to meeting the challenges of formulation, you need more than just an ingredient supplier. Review of disintegrants and the disintegration phenomena. Acetaminophen, disintegrants, wet granulation, intragranularly. The study assesses the suitability of excipients and superdisintegrants for developing an odt platform using conventional and nonconventional tests. Us4086335a us05626,988 us62698875a us4086335a us 4086335 a us4086335 a us 4086335a us 62698875 a us62698875 a us 62698875a us 4086335 a us4086335 a us 4086335a authority us. When manufacturing an odt, it is desirable to have tablets with acceptable hardness at a given compression force to produce robust tablets that avoid the. Disintegrant properties of native and modified polymers in. The dissolution test was conducted using the jp 16 paddle method. Improvement by super disintegrants of the properties of. Pdf evaluation of the disintegrant properties of native starches of.
Formulation design of fast disintegrating tablets using. The disintegrant potential of native starches of five new cassava manihot esculenta crantz. Effect of superdisintegrants on dissolution of cationic drugs j. Disintegrant definition of disintegrant by medical. Selecting superdisintegrants for orally disintegrating tablet. Disintegrants and superdisintegrants excipients for. The most accepted mechanism for tablet disintegration is by disintegrant swelling. Disintegrant is an excipient which is added to a tablet or capsule blend to aid in the break up of the compacted mass when it is put into a fluid environment. Pharmaceutical excipients are basically everything other than the active pharmaceutical. The mechanism involves rapid absorption of water leading to.
Department of health and human services food and drug administration. Below this concentration, the tablet disintegration time is inversely proportional to the concentration of the superdisintegrant, whereas if concentration of superdisintegrant is above critical. A design of experiments doe approach 2level full factorial design was used to investigate the effect of several formulation and process variables on the properties of fast disintegrating tablets. Cros carmellose sodium, crospovidone, fast disintegrating tablets. Disintegrants and superdisintegrants are used in tablets and capsules to ensure the rapid break down into their primary particles, facilitating.
Pharmaceutical excipients are basically everything other than the active pharmaceutical ingredient. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed. Intragranular incorporation proved to be the best method for optimum disintegrant property. With nounverb tables for the different cases and tenses links to audio pronunciation and relevant forum discussions free vocabulary trainer. Disintegrant is one of the most important components in a typical tablet dosageform. As the blends were free flowing angle of repose merriamwebster thesaurus, plus related words, definitions, and antonyms. Disintegrant can be used with products that are wet granulated, dry.
Evaluation of the disintegrant properties of native. Discover more about our excipients and active ingredients. In a wet granulation process, the drug substance is combined with other excipients and processed with the use of a solvent aqueous or organic with subsequent drying and milling to produce granules. It is responsible for ensuring the breakup of the tablet matrix upon ingestion. Disintegrant definition of disintegrant by medical dictionary.
To inter a body is to bury it or place it in a mausoleum, so to disinter someone is to take the body out again usually to find out how they died, to make sure its really who we think it is, or to move the body. A disintegrant is an agent, used in the preparation of tablets, which causes them to. The study may ultimately help in selection of the best. The disintegrant property of dried pods of okra was investigated in. Liquid is drawn up or wicked into these pathways through capillary action and rupture the inter particulate bonds causing the tablet to break apart as shown in fig 1. The disintegrant must quickly wick saliva into the tablet to generate the volume expansion and hydrostatic pressures necessary to provide rapid disintegration in the mouth. Definition of pharmaceutical excipients pharma excipients. For example, levothyroxine, a synthetic form of the thyroid hormone, indicated in the treatment of hypothyroidism, is administered at a very.
Preparation and evaluation of solid dispersion tablets by. The disintegrant can be incorporated either intragranularly, extragranularly or it can be distributed both intra and extragranularly. Disintegrant is the term applied to various agents added to tablet granulation for the purpose of causing the compressed tablet to break apart disintegrate when placed in an aqueous. Below this concentration, the tablet disintegration time is inversely proportional to the concentration of the superdisintegrant, whereas if concentration of superdisintegrant is above critical concentration, the disintegration time remains almost constant or even increases kaur t et al. Apr 18, 20 active substances are rarely administered alone. The word excipient is derived from the latin excipere, meaning to except, which is simply explained as other than. Studies on disintegrant properties of seed mucilage of ocimum gratissimum.
Disinter definition is to take out of the grave or tomb. Although many reports are available in the literature where superdisintegrants in wet granulated tablets have been examined using single mode of incorporation 811 not many reports are available in. Starch amylum the mechanism of action of starch is wicking and restoration of deformed starch particles on contact with aqueous fluid and in doing so release of. Heat and certain other physical agents such as live steam can be disinfectants, but in. Superdisintegrants international journal of pharmaceutical.
New database which consist most of the words with oxford dictionary. Water penetration rate and rate of disintegration force development are generally positively related to disintegrant efficiency in nonsoluble matrices. Type and mechanism of tablet disintegrant formulation. Pdf the disintegrant potential of native starches of five new cassava manihot esculenta crantz. For example, levothyroxine, a synthetic form of the thyroid hormone, indicated in the treatment of hypothyroidism, is administered at a very low dosage, ranging from 15. International journal of research in ayurveda and pharmacy 2010. English malayalam dictionary malayalam english dictionary english english add on database english add on. In a wet granulation process, the drug substance is combined with other. The improved properties of the tablets containing insoluble super disintegrants, when compared to tablets with potato starch, are the result of the use of a much lower concentration of. Pdf in the present work, fast disintegrating tablets of. Synonyms for disintegrate include collapse, fragment, shatter, splinter, crumble, break up, fail, founder, fracture and decline. Roquette has developed a versatile range of standard disintegration excipients. Synonyms for disinterested include impartial, objective, unbiased, equitable, unprejudiced, detached, neutral, dispassionate, evenhanded and impersonal.
Heat and certain other physical agents such as live. Disintegrating crossword answers, clues, definition. Cros carmellose sodium, crospovidone, fast disintegrating tablets, prochlorperazine maleate. A disintegrant is an excipient that is incorporated into the formulation of tablets or capsules to promote their disintegration when they come into contact with liquid or fluid matter.
Several types of disintegrant have been routinely used for many years and may be distinguished according to their mode of action. These very small amounts of powder mean that it is not possible to manufacture tablets containing only this drug. In other words, the ability for starch to swell is. English malayalam dictionary, this is an absolutely freeware and fully offline english to malayalam dictionary. Comparison of superdisintegrants in orally disintegrating. Learn the translation for disintegrant in leo s english. The binder and disintegrant were selected from 7 and 4 candidates, respectively. May 28, 2015 disintegrant is the term applied to various agents added to tablet granulation for the purpose of causing the compressed tablet to break apart disintegrate when placed in an aqueous environment. Fast disintegrating tablets using disintegrant blends. A total of four formulations and a control formulation dc 0 without superdisintegrant were designed. You must there are over 200,000 words in our free online dictionary, but you are looking for one thats only in the merriamwebster unabridged dictionary start your free trial today and get unlimited access to americas largest dictionary, with. Odt formulations optimal combinations of excipients and.
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